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In addition, H 2 significantly reduces intracellular ROS by upregulating Nrf2 transcription to promote the expression of SOD and glutathione (GSH) and downregulating the expression of NADPH oxidase (Su et al., 2019

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Activating PINK1/Parkin-mediated mitophagy in macrophages can prevent and treat AS ( Other studies have shown that regulating mitophagy disorders can reduce cardiomyocyte damage and improve cardiac function

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Serious adverse reactions are exceptionally rare