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HPLC-DAD The HPLC-DAD system (Shimadzu, Kyoto, Japan) consisted of an auto-sampler (SIL-20A), a liquid chromatograph (LC-20AD), and a diode array detector (SPD-M20A)

It is synthetically produced by a process fermentation, derived from corn starch

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Predominantly gastrointestinal nausea, diarrhea, vomiting, constipation, and decreased appetite all dose-dependent and most common after a dose or an escalation

These effects were associated with decreased androgen receptors, mTOR and AKT expression signaling, and increased caspase-3 activation 35

Cervenka, F