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Analysis of supportive secondary endpoints: Semaglutide 2.4 mg was also associated with improvements in multiple cardiovascular risk factors, including waist circumference, glycated haemoglobin level, systolic and diastolic blood pressure, high-sensitivity C-reactive protein and lipids

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Even with these limitations, wanting-related measures show a relatively recurring pattern of reduced craving or reduced responsiveness to highly palatable food cues across several studies

Given that cellular senescence is now recognized as one of the primary pillars of biological aging, this third mechanism elevates MOTS-c from a metabolic peptide to a potential geroscience intervention

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