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Due to a short plasma half-life of native GLP-1, several synthesized GLP-1 receptor agonists (RAs) were developed for type 2 diabetes mellitus (DM) treatment

Some patients require higher doses or benefit from combination therapy like PlexusDx's GLP-Squared injection (semaglutide plus tirzepatide)

The JCA implementation through 2025-2026 will generate the first real-world data on whether EU Joint Clinical Assessments improve or complicate national HTA outcomes

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