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Concurrently, it enhances the expression of dopamine D1 and D2 receptors and serotonin within the HPA axis, thereby improving sleep quality [135, 136]

This indicated that restoring the levels of AngIV may have a positive effect on the progression of AD

Funding The research in the authors laboratory was supported by the National Natural Science Foundation of China Grant (No.8217140592, No.81673671) and Special National Key Research and Development Plan (No.2016YFC1306305 J-DX)

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In addition, presence of high concentrations of polyunsaturated fatty acids in the brain enhances their peroxidation and generation of toxic products which further causes degeneration of the cells harboring them or in vicinity 22