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Osteoarthr Cartil 26(2):165174 Woodell-May JE, Sommerfeld SD (2020) Role of inflammation and the immune system in the progression of osteoarthritis

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Low-level local ROS are significant because they regulate critical transcription factors (NFB/IB, Nrf2/KEAP1, AP-1, p53, HIF-1) and act as redox-signaling molecules in a variety of pathways involved in ensuring the maintenance of cellular homeostasis (MAPK/ERK, PTK/PTP, PI3K-AKT-mTOR)

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However, some individuals may experience mild gastrointestinal discomfort

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