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Diabetes: metformin + one other agent for 90 days each Weight loss: 6-month lifestyle program + trial of phentermine or orlistat If yes: 65% approval probability on first PA submission If no: 12% approval probability, expect step-therapy denial This framework correctly predicts coverage outcome in 84% of cases based on our patient intake data patterns

Figure 8 6.4 Heart diseases and polyphenols Globally, cardiovascular diseases are the leading cause of mortality, according to data from the World Health Organization (WHO)

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the study physician attributed the death to pre-existing coronary artery disease unrelated to the drug, but the FDA's Pharmacy Compounding Advisory Committee cited this "unresolved cardiac signal" in December 2024 as a reason to keep the compound off the approved compounding list

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However, whether TMAO plays a role in this has not been reported thus far and merits further investigation