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What about extracellular reactive nitrogen species

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A deficiency in vitamin B12 can lead to a range of symptoms, including fatigue, weakness, numbness or tingling in the hands and feet, difficulty walking, and memory problems

FEBS Lett 425:528529 Foyer CH, Souriau N, Perret S, Lelandais M, Kunert KJ, Pruvost C, Jouanin L (1995) Overexpression of glutathione reductase but not glutathione synthetase leads to increases in antioxidant capacity and resistance to photoinhibition in poplar trees

Yes, actually - they're made to work as a set

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