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Key proteins differentially regulated by cotadutide in the insulin signaling network included the insulin receptor (INSR), RAS, mTORC1 up- and down-stream components, (DEPTOR, LAMTOR1, LARP1, RPS6, TSC1, PRKAB1), regulators of PI3K signaling (INPPL1, INPP5F, and PIK3C2A), and regulators of glycogenesis/glucose (GCKR, GYG2, PPP1R3G, PHK and PYGL) (Fig