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The drug has rapid pharmacokinetics with intravenous administration, an onset of action within 12 minutes, and a short half-life of approximately 2 minutes, leading to increases in systolic blood pressure (1020 mmHg) and heart rate (515 bpm)

Strategies may include sipping water throughout the day, replacing electrolytes when needed, avoiding foods or drinks that trigger symptoms ( dairy is a common culprit in people with lactose intolerance), and limiting caffeine and alcohol

It puts most patients at 1.2 to 1.6 grams of protein per kilogram of body weight daily to preserve lean muscle during caloric restriction

But as patients began shedding significant pounds, researchers took notice

Also, results may vary from individual to individual

PPAR, peroxisome proliferator-activated receptor