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Its becoming a multi-disease cardiometabolic platform spanning: Cardiovascular disease Obstructive sleep apnoea (OSA) MASH Chronic kidney disease And importantly: Oral obesity therapy is now real not theoretical But the category is already splitting: Peptide oral (with friction) Small-molecule oral (lower friction) That distinction will matter more than pill vs injection Peptide oral (with friction) Small-molecule oral (lower friction) That distinction will matter more than pill vs injection The Most Misunderstood Opportunity: OSA OSA has gone from interesting to commercially meaningful fast Tirzepatide is now the first approved drug for OSA in obesity Phase 3 data showed:~2529 events/hour reduction in AHI Up to ~50% reaching disease-resolution criteria Thats real

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Tafuri A, Meyers J, Lee BJ, Andreeff M

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Its a process that brings increased blood flow and heightens defenses around an area that is damaged

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