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Canonical markers of necroptosis a
The process of generating ATP naturally produces reactive oxygen species (ROS), which are highly volatile molecules that can cause severe cellular damage if left unchecked
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In rats with portosystemic shunts, induction of systemic oxidative stress in the setting of hyperammonemia led to brain edema, supporting that neither hyperammonemia nor oxidative stress alone, but their synergistic interaction, contributes to the pathogenesis of brain edema in HE [62]
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