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Hormones sit underneath all of this

Research published in a 2025 narrative review found that GLP-1 medications can lead to muscle loss, micronutrient deficiencies, and digestive disruptions if nutritional needs aren't actively managed

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Exendin-4 increases intracellular cAMP levels in colon cancer CT26 cells, activates the PKA pathway, and inhibits the activity of signaling kinases GSK3 and ERK1/2, consequently suppressing CT26 cell proliferation (152)

Novo Nordisk prices it at a premium because weight management patients represent a larger, less price-sensitive market than type 2 diabetes patients

Common side effects include nausea, diarrhea, and mild gastrointestinal discomfort, usually dose-dependent