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Statistical significance was assessed using analysis of variance (ANOVA) followed by Tukeys multiple comparison tests

Importantly, a phenotype-oriented approach may improve clinical relevance, where MI may be prioritized in insulin-resistant individuals, vitamin D in deficient or inflammatory phenotypes, and melatonin in patients with pronounced oxidative stress or circadian disruption

These patients are usually characterized by an increased abundance of Bacteroidetes and Proteobacteria, and a lower abundance of Firmicutes and Bifidobacteria

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