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Excessive glutamate in the PFC and striatum has also been linked to withdrawal symptoms (Hinton et al., 2012

Joshua Silva, MD Nov 7, 2025 13 min read Updated: Apr 17 Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD As GLP-1 and GLP-1/GIP medications such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) continue to transform medical weight management, one question comes up repeatedly: Do these medications cause muscle lossor even muscle wasting

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This lines up with how antioxidant and skin-related changes are usually measured in available research, rather than the one-week timelines sometimes implied in marketing