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When we talk about bioavailability, we are talking about the portion of a nutrient that enters the circulation and is able to have an active effect

Ethics declarations Competing interests M.M.V., S.C.L., L.A., R.K., S.S., Y.C., B.W., J.R.F., T.H., V.A.T., M.A., L.S., Y.Z., V.K., R.J., R.K.O., J.R.P., N.H

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43 These interactions enable lactate to regulate cytokines, chemokines, adhesion molecules, and signaling pathways (Figure 1) for the expression of several enzymes taking part in immune response and metabolism, elucidating its differential effects on inflammatory processes beyond its role as a well-known metabolic waste product

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(PubMed) Naghashpour M, Amani R, Sarkaki A, et al