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Patients typically move to 5 mg, then 7.5 mg, 10 mg, 12.5 mg, and finally 15 mg as the maximum dose

In the -oxidation pathway, short-chain acyl-CoA dehydrogenase (SCAD, ACADS) catalyzes the oxidative conversion of butyryl-CoA to crotonyl-CoA [53, 54], which serves as the essential substrate for protein crotonylation

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