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Similarly, drugs like nintedanib inhibit multiple tyrosine kinases involved in the fibrotic process, suppressing fibroblast proliferation and differentiation [264]

Animal toxicology studies spanning three decades have found no evidence of mutagenic, genotoxic, or carcinogenic effects

While these effects drive significant weight loss, they can also lead to reduced food intake and potentially inadequate consumption of essential nutrients

In direct ablation, the laser decomposes the skin target into small fragments, moving away from the skin surface at supersonic speed [187] This reduces the skin barrier function, enabling efficient transport of macromolecules

increase circulatory volume

The stationary phase mostly consists of agarose or synthetic polymers and is packed into a column in the form of beads