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NNMT catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM, the universal methyl donor in cells) to nicotinamide (a form of vitamin B3 and a precursor for NAD+ synthesis), producing 1-methylnicotinamide and S-adenosylhomocysteine (SAH)

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Abstract There are currently no satisfactory effective treatments for osteoarthritis (OA), the most common degenerative joint disease leading to progressive disability in the elderly population

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