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Resistance is often associated with the accumulation of reactive oxygen species (ROS) and programmed cell death at the sites of infection (hypersensitive response, HR) (Barna et al., 2012

NIH.gov (2026) lists it as experimental, not substituting FDA-approved treatments like minoxidil

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The EXPLORER study, which focused on moderately-to-severely active extrarenal SLE, found no significant difference between Rituximab and placebo across primary and secondary endpoints (118)