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As Bellomo put it, The evidence is approaching the threshold where practical planning should begin in earnest, even as we await data on sustained real-world outcomes. GLP-1 medications may ultimately become an important driver of cardiometabolic health improvement, but translating clinical promise into measurable mortality experience will take years of real-world data

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Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight

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