Some notable safety-related conclusions from scientific materials include: A 2016 review of TB4 for dermal healing: The safety profile is excellent, and no preclinical toxicology has been found.22 A 2016 clinical trial on patients with STEMI: Our pilot study suggested that T4-optimized EPC transplantation appeared to be feasible and safe.34 A 2021 review of TB4 research: It was well tolerated and safe in healthy people and suitable for use in a clinical study.21 Though the compound itself may be generally safe for adults to use, some common side effects from TB4 injections reported by patients and doctors include: Injection site reactions (e.g., redness, mild swelling, or pain) Mild gastrointestinal symptoms Headaches and dizziness Rare but more serious side effects can include fever, blistering at the injection site, muscle aches, skin rash, vomiting, severe itching, or hives

Pause-and-resume for nausea or GI events is uncommon in community reports for melanotan-1 (less common than for melanotan-2)
Cai J, Chen Y, Seth S, Furukawa S, Compans RW, Jones DP
Evidence (larotrectinib): An expanded pooled efficacy analysis included 159 patients with TRK fusionpositive cancers treated with larotrectinib
Effect of variations in small intestinal glucose delivery on plasma glucose, insulin, and incretin hormones in healthy subjects and type 2 diabetes
Plus, the PIs for these two medications give more focus to the top 56 side effects experienced by participants in clinical trials, which include nausea , vomiting, diarrhea, abdominal pain, and constipation