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At 6 months, patients who discontinued treatment within 0-3 months had a -1.8% weight change, while those persistent for 12 months saw an -8.1% change

The signals originate in stretch and chemical receptors that sense GI-luminal content (qualitative and quantitative) and are transmitted via release of hormones from enteroendocrine cells (EEC) or through nerves, initially the enteric nervous system (ENS)

If a basal insulin plus rapid-acting insulin regimen is used, a survival programme will be required, the benefits of basic TED should be taken into consideration, and if a greater demand is expected, advanced TED may be needed

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