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doi: 10.1111/bph.17425 50 YinD.XiongH

Key gaps include: No large-scale randomised controlled trials in humans the evidence basis for clinical use is extrapolated from animal data and small pilot studies No long-term safety data effects beyond 1216 weeks are not well characterised Variable results in human sleep trials some early human studies showed modest or inconsistent effects on sleep architecture compared to animal data, suggesting the translation may not be linear No FDA approval DSIP is not approved for any therapeutic use in the United States Stability concerns DSIP degrades relatively quickly in circulation

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We proposed that GSH catabolism by cells with high GGT activity can support surrounding cells in a paracrine fashion

Your legs might look like the vein disease got worse when really the veins were already there just masked by surrounding fat tissue