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These findings were supported by the relaxation of large vessels (ex vivo), mainly by acting on vascular endothelial cells but also on vascular smooth muscle cells, increasing NO production and migration of endothelial cells, activating the signal pathways of Src, Cav-1, and eNOS, and reducing proteinprotein interaction between eNOS and Cav-1 [121,122]

Using forceps, the stimulus was applied to the rats hind limb by momentarily pinching the areas innervated by the tibial, fibular, and sural nerves

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This dysfunction, in turn, may play a role in the increased vulnerability to vascular disease and T2DM observed within this particular cohort

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics