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Ongoing research continues to explore potential effects on appetite-regulating hormones including leptin, ghrelin, and peptide YY, with preliminary data suggesting complex interactions that may contribute to sustained weight loss beyond simple caloric restriction

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As mentioned above, the lPBN of the pons is heavily implicated in the aversive and non-aversive control of feeding via CGRP-expressing and non-CGRP-expressing neurons, respectively