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In the canonical GPX4-dependent pathway, p53 suppresses SLC7A11 to reduce cystine uptake, leading to GSH depletion and impaired GPX4 activity, thereby promoting ferroptosis
Farah had just finished a paper in which she reviewed the evidence on prescription stimulants as neuroenhancers from forty laboratory studies involving healthy subjects
(2001) Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Softic S., Gupta M.K., Wang G.-X., Fujisaka S., ONeill B., Rao T.N., Willoughby J., Harbison C., Fitzgerald K., Ilkayeva O., et al
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Because DHEA is only converted into sex steroids in target tissues containing the relevant physiologic enzymatic machinery, it has been suggested that it could be used for treating estrogen-deficient wound healing without deleterious systemic side effects (Pomari et al., 2015)
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