Among them, SOD is an important antioxidant enzyme class that exclusively defends against excessive O2- during metabolic processes in the organism, and its activity level indirectly reflects the degree of oxidative damage suffered by the organism (Liu et al., 2019), but the highest concentrations are found in the liver, biliary epithelium and bone (Peng et al., 2015), the enzyme levels of AKP and ACP are greatly increased (Shang et al., 2003)
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Physical activity, dietary changes, and other microbiota-targeted intervention strategies discussed in this review are extremely beneficial in CKD management as they offer a non-invasive approach to the reduction of uremic toxins, enhancement of the intestinal barrier integrity and that of the BBB, lowering inflammation and oxidative stress, SCFAs generation, modulation of neurotransmitter levels, and immune responses that ultimately slow kidney function decline, decreasing the occurrence of associated complications, and greatly improving the quality of lives of affected individuals
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Because this was an observational study and there was no control group for the analysis of efficacy or harms, the findings are at high risk of confounding
