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Cardiovascular Health Numerous clinical trials have shown that GLP-1s produce substantial and sustained weight loss in both diabetic and nondiabetic populations.[134] Beyond their metabolic effects, these therapies have shown notable cardiovascular benefits, underscoring their broader clinical utility, particularly in high-risk groups
Up to now all the prospective GPR119 agonists were plagued by low bioavailability, lack of efficacy and more importantly, cardiotoxicity which has stopped all human studies before any large scale Phase III clinical trials (239)
J Pediatr Hematol Oncol 42(1):e25e31 Ramkumar V, Mukherjea D, Dhukhwa A, Rybak LP (2021) Oxidative stress and inflammation caused by cisplatin ototoxicity
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doi: 10.1002/cld.929 [PubMed] 33409766 Redant S, Empain A, Mugisha A, Kamgang P, Attou R, Honor PM, De Bels D