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Growing evidence indicates ferroptosis in AD pathogenesis, with studies reporting iron accumulation, dysregulated antioxidant systems, elevated lipid peroxidation, and impaired anti-ferroptotic defenses in AD brains [115]

Various small-molecule inhibitors targeting different stages of NLRP3 activation have been developed and investigated preclinically

Why the FDA Boxed Warning Exists The FDA boxed warning states GLP-1 receptor agonists should not be used in patients with MTC history or MEN2