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[12] Falutz J, Mamputu JC, Potvin D, et al

Science 385 , eadl5763 (2024)

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Exosomes are cell-derived nanovesicles carrying growth factors and signaling molecules that can stimulate dermal papilla cells and activate hair follicle stem cells

Within hours after cleaning, teeth become coated with a layer of salivary proteins, which can isolate antibacterial materials from bacteria, thereby reducing antimicrobial efficiency and long-term efficacy ( In addition to the two aforementioned oral-specific environmental resistance factors, the clinical translation of nanomaterials currently faces several challenges:(1) the long-term biosafety, biocompatibility, and functional durability of these nanomaterials within the oral cavity require rigorous assessment in live animal models and, ultimately, clinical trials (Sajithkumar et al., 2025)

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