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Studies have shown that metformin has antitumor activity in the major gynecologic malignancies through a pleiotropic mechanism involving direct silencing of IGF-1R signaling and indirect silencing of this signaling pathway by targeting its downstream targets, including MAPK and mTOR (21, 22)

Genet Sci 21(1):102106 Al Qurashi M et al (2023) Incidence of inborn errors of metabolism in newborn infants: five years single-center experience, Jeddah, Saudi Arabia

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Consequently, NAD is vital for maintaining the stability and integrity of genetic material within nerve cells, essential for the proper functioning and survival of neurons (13, 14)