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Association among polymorphisms in the steroid 5-reductase type II (SRD5A2) gene, prostate cancer risk, and pathologic characteristics of prostate tumors in an Ecuadorian population

Less Common but Serious Risks Pancreatitis (inflammation of the pancreas) Gastroparesis (severely delayed stomach emptying) Gallbladder complications, including gallstones Bowel obstruction (rare but documented) Thyroid Considerations All GLP-1 receptor agonists carry a boxed warning based on animal studies showing thyroid C-cell tumors in rodents

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hippocampal CA3 synapse loss, suppressed neurogenesis and chronic-stress BDNF reduction

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Safety considerations and side effects BDNF modulation is not without risks