However, the cognitive enhancing effects of PregS in healthy subjects are unlikely to be due to the PREG metabolite ALLO since acute administration of this and other GABAergic modulating neurosteroids to healthy subjects inhibits learning and memory function in a manner similar to benzodiazepines (187191)
PubChem Reference: View compound profile on NIH PubChem Key Characteristics MOLECULAR PROFILE Formula: C 38 H 49 N 9 O 5 Weight: 711.86 g/mol CAS: 170851-70-4 Structure: Aib-His-D-2-Nal-D-Phe-Lys PHYSICAL PROPERTIES Form: White to off-white lyophilized powder Solubility: Readily dissolves in water Selectivity: High receptor selectivity Storage: Keep refrigerated 3646 F (28 C)
Its safe to use in the sense that it wont cause harm, but its biologically inactivedegraded peptide fragments dont bind collagen receptors or inhibit matrix metalloproteinases, so you lose the anti-ageing effect
Similarly, Liebmann et al
J., Malatynska E., Collins N., Fang L., Wang J
The frequency, severity and disability of headache were decreased after 3 months
