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In this context, shifts in KP metabolism may promote a neuroprogressive state in MDD by coupling oxidative stress to impaired bioenergetics, synaptic dysfunction, and neuronal loss

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2025 milestone: Combined Mounjaro and Zepbound sales of $36.5 billion made tirzepatide the worlds best-selling drug in 2025 surpassing Novo Nordisks combined semaglutide portfolio ($33 billion) and Mercks Keytruda ($31.7 billion)

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PMID: 38733771 SSRN2023 Nov 17

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