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Furthermore, when comparing the combination therapy to the standard treatment, Donepezil, the reduction in A plaque burden in both the cortex and hippocampus was similar between the groups, while the combination group showed a trend towards lower levels of soluble A

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This ratio is one of the most reliable biomarkers of cellular redox status, measurable by HPLC or enzymatic assay (Forman et al., Mol Aspects Med 2009)

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