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This is not a pharmacokinetic effect but rather a physiological one

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In response to these findings, the European Medicines Agency (EMA) conducted a review and concluded that NAION is a very rare adverse reaction to semaglutide-containing products, potentially affecting up to 1 in 10,000 users

Chan School of Public Health, said in the article

[But now I realize] there are patients who would benefit from these medications. He emphasizes that, when prescribed in concert with other comprehensive lifestyle interventions, including physical therapy, resistance training, and healthy eating, GLP-1s can be promising, so long as clinicians proceed with caution