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Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

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Additionally, increased MCP-1 levels are associated with heightened blood-brain barrier (BBB) permeability, further complicating disease pathology by allowing more inflammatory cells to infiltrate the CNS [26]

The telling sign of this is elevated homocysteine and methylmalonic acid despite normal folic acid, B6, & B12 levels (11)

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