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ALX-0171 a trivalent nanobody targeting the fusion protein of respiratory syncytial virus achieves efficient deposition in the lower respiratory tract, potently neutralizing respiratory syncytial virus at early stages of infection and reducing viral replication in preclinical models 238,239

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10.1016/j.jad.2023.04.003 242 KiriyamaY.NochiH

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Enzymes that produce ROS, including ALOX, xanthine dehydrogenase, NADPH oxidase, and the mitochondrial electron transport chain complex, bind to iron, heme, or iron-sulfur clusters