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This analogue also demonstrated the most pronounced detoxifying effect towards cisplatin action, resulting in a decrease in the animal death from the acute cisplatin toxicity to 17% (in comparison with 50-67% for the control animals) and restoration of a number of cisplatin-sensitive biochemical blood parameters: decrease in the activity of aspartate aminotransferase and alanine aminotransferase and downregulation of the concentration of the final products of nitrogen exchange (creatinine and urea)

The x cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases

Some differences were observed between our conditional knockout models

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Retatrutide delivers 24.2% weight loss vs Zepbound (20.9%) and Wegovy (14.9%)