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The variation in blood concentration of thyroid hormone causes a change in gastrointestinal neuromotor function, leading to the occurrence of gastrointestinal dysfunction, which can be clinically manifested as constipation and intestinal obstruction [141]

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30,35 At therapeutic doses, whether GLP-1RA can directly affect the CNS depends on the drugs properties

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Schirra J, Nicolaus M, Woerle HJ, Struckmeier C, Katschinski M, Gke B, et al