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The primary reasons for exclusion were withdrawal from follow-up at the participants discretion, treatment discontinuation due to nausea, drug supply issues, cholangiocarcinoma, pancreatitis, and treatment cessation at a non-participating institution ( Figure 1 )

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129 Preclinical studies in various PD animal models indicate that GLP-1RAs such as liraglutide, semaglutide, and lixisenatide promote dopamine synthesis and elevate striatal dopamine levels, thereby conferring neuroprotection to dopaminergic neurons

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