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We observed nearly complete downregulation of HIF-1 protein level as early as 6 h of treatment with ESI-09 preceding a 15-fold downregulation of TXNIP mRNA seen at 12 h
Moreover, mitochondrial defect is an important component in the pathogenesis of schizophrenia as reviewed in the next section
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and, according to Hyman, has long been used to treat liver disease (12)
BMC Gastroenterology , 17 (1), 96
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