tirzepatide and kidney stones Changes in 24-Hour Urine Chemistry in Patients with Nephrolithiasis during Weight Loss with Glucagon-Like Peptide 1–Based Therapies Ozempic May Help Treat Kidney

And dangerous

By combining these therapies with guidance on nutrition, exercise, and healthy habits, we help patients reach their weight management goals safely and effectively

That means they were more at risk than the general population

New York, NY, USA: 2021

Research suggests that Akt-mediated eNOS phosphorylation may increase nitric oxide (NO) bioavailability within vascular tissue microenvironments, potentially supporting vasodilation, microvascular integrity, and organized angiogenic responses in tissues with limited baseline vascular supply such as tendon, ligament, and fibrocartilaginous structures

It does not mean the drug has stopped working