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For example, deguelin can suppress tumor angiogenesis on vascular endothelial cells by decreasing autocrine VEGF and repressing HGF-induced c-Met signaling pathways, thereby inhibiting HCC progression ( Centella asiatica ( Resistance in c-Met Inhibitors and Sorafenib and Combined Inhibition of HGF/c-Met and Other Pathways C-Met inhibitor therapy has failed to result in satisfactory outcomes in phase III clinical trials for HCC

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