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It can be calculated from the product of the fraction absorbed across the gut (f) and the hepatic extraction ratio (ER)

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Thoene J, Lemons R, Anikster Y, Mullet J, Paelicke K, Lucero C, Gahl W, Schneider J, Shu SG, Campbell HT (1999) Mutations of CTNS causing intermediate cystinosis

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