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Ceriello A, Novials A, Ortega E, Canivell S, La Sala L, Pujadas G, et al

On 24 November 2025, Novo Nordisk reported that oral semaglutide had failed to slow Alzheimers disease in the EVOKE and EVOKE+ trials, which together enrolled 3,808 participants and stand as the largest evaluation of this drug class in any neurodegenerative condition [1]

Researchers are still studying why this happens

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