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Diabetes Care (2004) 27:262835

Key Takeaways Retatrutide is an investigational weight-loss drug showing strong results in trials, but it is not FDA-approved yet

In contrast, Noom states that their dosing starts at 25% or less of the standard 0.25 mg dose and escalates at a personalized rate. While microdosing GLP-1 medications may provide a more personalized experience, there are still questions regarding the safety of this practice as there are currently no published studies on the process, and the microdoses may come from a compounding pharmacy

It typically takes about 48 weeks before changes in appetite and weight become apparent, and consistent loss tends to build over months as the medication reaches its optimal effect

It suppresses appetite, stimulates insulin release, and promotes fat breakdown in the body

Cureus 13 , e15141 (2021)