Its been noted that folic acid fortification in food helps to lower the prevalence of neural tube defects by about 50% to 70%
Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease
GLP-1 agonists reduce caloric intake, which drives weight loss but does not specifically target visceral or subcutaneous fat
This paradoxical improvement occurs because pain reduction outweighs any stimulatory effect on neurotransmitters
Follow-up question: Thanks for taking the time to reply to my post Lisa
Groups at higher risk of deficiency include older adults (due to reduced stomach acid production), vegans and vegetarians, people with pernicious anaemia or gastrointestinal disorders affecting absorption, and those taking certain medications such as metformin or proton pump inhibitors
