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There are no major contraindications identified with GHK-Cu, and it is considered safe for extended use

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Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, et al

The mice were euthanized through CO2 inhalation when the tumor volume surpassed 1500 mm or when the mice showed signs of serious weight loss, dreadful weakness, or Unhealed ulcers, indicating they were moribund

The distinct structural makeup and presence of functional groups such as hydroxyl and methoxyl groups contributed to the drug-sensitizing ability of the polyphenols

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